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Recombinant Porcine Interleukin-1 beta

英文名：
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
1308132719-10 μg 0 ￥3800 请登录
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1308132719-50 μg 0 ￥11800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Porcine Interleukin-1 beta 能调控炎症反应，参与细胞增殖、分化、凋亡等多种细胞生命活动。
Synonyms
rPoIL-1β; IL1B ; 重组猪白细胞介素-1 β
Species
Porcine

Source
E. coli

Accession
P26889

Gene ID
397122

Molecular Weight
Approximately 17.7 kDa

AA Sequence
MANVQSMECK LQDKDHKSLV LAGPHMLKAL HLLTGDLKRE VVFCMSFVQG DDSNNKIPVT LGIKGKNLYL SCVMKDNTPT LQLEDIDPKR YPKRDMEKRF VFYKTEIKNR VEFESALYPN WYISTSQAEQ KPVFLGNSKG RQDITDFTME VLSP

Biological Activity
The ED50 is <1 ng/mL as measured by mouse D10S cells, corresponding to a specific activity of >1.0 × 106 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Porcine Interleukin-1 beta (rPoIL-1β) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Porcine Interleukin-1 beta (rPoIL-1β) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-1 beta (IL-1 β) is one of the major inflammatory cytokines found in atherosclerotic lesions[1]. Interleukin-1β (IL-1β) acts throughout the IL-1β system, which contains IL-1β and the IL-1β receptor (IL-1R), accessory protein (IL-1RacP), and receptor antagonist (IL-1Ra). In pigs, the expression of the members of the IL-1β system was documented in uterine tissues during the oestrous cycle and early pregnancy, as well as in embryos harvested during the peri-implantation period[2]. Interleukin-1 beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells[3].

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