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Recombinant Rat Insulin-like Growth Factor-I
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| 性状 | Recombinant Rat Insulin-like Growth Factor-I 具有生长激素活性和有效促进神经元存活的能力。
Synonyms rRtIGF-I; Somatomedin C; IGF1; Mechano growth factor ; 重组大鼠胰岛素样生长因子1 Species Rat Source E. coli Accession P08025 Gene ID 24482 Molecular Weight Approximately 7.8 kDa AA Sequence MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPTKS A Biological Activity The ED50 is <10 ng/mL as measured by FDCP-1 cells, corresponding to a specific activity of >1.0 × 105 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat Insulin-like Growth Factor-I (rRtIGF-I) to 100 μg/mL using ddH2O. Storage & Stability Lyophilized recombinant Rat Insulin-like Growth Factor-I (rRtIGF-I) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IGF-I (Insulin-like Growth Factor-I) has somatomedin activity. IGF-I stimulates the growth of hypophysectiomized rats in a dose-dependent manner[1]. Circulating IGF-I plays a prominent role in normal growth and development by mediating the indirect effects of growth hormone, with which it has a complex relationship. Delivery of IGF-I to the CNS may be beneficial in the treatment of Alzheimer’s disease or stroke because of IGF-I’s ability to potently promote neuronal survival, rescue hippocampal neurons from β-amyloid induced neurotoxicity, reduce tau phosphorylation, protect cortical neurons against nitric oxide-mediated neurotoxicity, rescue neurons from glucose deprivation and stimulate neurogenesis and synaptogenesis[2]. |
| 贮存 |
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