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Recombinant Rat Insulin-like Growth Factor-I

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132716-10 μg 0 ￥1400
- +
1308132716-50 μg 0 ￥2800
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。
别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Rat Insulin-like Growth Factor-I 具有生长激素活性和有效促进神经元存活的能力。
Synonyms
rRtIGF-I; Somatomedin C; IGF1; Mechano growth factor ; 重组大鼠胰岛素样生长因子1
Species
Rat

Source
E. coli

Accession
P08025

Gene ID
24482

Molecular Weight
Approximately 7.8 kDa

AA Sequence
MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPTKS A

Biological Activity
The ED50 is <10 ng/mL as measured by FDCP-1 cells, corresponding to a specific activity of >1.0 × 105 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Rat Insulin-like Growth Factor-I (rRtIGF-I) to 100 μg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Rat Insulin-like Growth Factor-I (rRtIGF-I) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
IGF-I (Insulin-like Growth Factor-I) has somatomedin activity. IGF-I stimulates the growth of hypophysectiomized rats in a dose-dependent manner[1]. Circulating IGF-I plays a prominent role in normal growth and development by mediating the indirect effects of growth hormone, with which it has a complex relationship. Delivery of IGF-I to the CNS may be beneficial in the treatment of Alzheimer’s disease or stroke because of IGF-I’s ability to potently promote neuronal survival, rescue hippocampal neurons from β-amyloid induced neurotoxicity, reduce tau phosphorylation, protect cortical neurons against nitric oxide-mediated neurotoxicity, rescue neurons from glucose deprivation and stimulate neurogenesis and synaptogenesis[2].
贮存
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