Recombinant Human Interleukin-17F 在炎症反应中有多种功能,在一些肿瘤发生过程中起保护作用。 Synonyms rHuIL-17F; Cytokine ML-1 ; 重组人白细胞介素-17F Species HumanSource E. coli Accession Q96PD4 Gene ID 112744 Molecular Weight Approximately 30.1 kDa AA Sequence MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ Biological Activity The ED50 is <20 ng/mL as measured by murine NIH/3T3 cells, corresponding to a specific activity of >5.0 × 104 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.2, with trehalose. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-17F (rHuIL-17F) to 100 μg/mL using 4 mM HCl. Storage & Stability Lyophilized recombinant Human Interleukin-17F (rHuIL-17F) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Human Interleukin-17F could induce pulmonary neutrophilia and amplifies antigen-induced allergic response[1]. IL-17F has been shown to have multiple functions in inflammatory responses and plays an important role in the tumorigenesis of human colonic epithelial cells.. Similar to IL-17A, IL-17F induces the production of many pro-inflammatory cytokines (IL-6/GM-CSF) and chemokines (CXCL1/2/5) in different cell types, as well as enhances granulopoiesis and neutrophil recruitment[2]. |