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IkappaB-alpha Phospho (S32) (NFKBIA)

英文名：IkappaB-alpha Phospho (S32) (NFKBIA)
Cas号：
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别 名 NFKBIA antibody, IKBA antibody, MAD-3 antibody, NFKBI antibody, NF-kappa-B inhibitor alpha antibody, Major histocompatibility complex enhancer-binding protein MAD3 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】The NF-kappaB/Rel transcription factors
are present in the cytosol in an inactive state,
complexed with the inhibitory IkappaB-alpha protein
(1-5). In response to many different NF-kappaB-
inducing agents including T-cell mitogens,
proinflammatory cytokines, and viral transactivators,
the inhibitory IkappaB-alpha is rapidly phosphorylated
and degraded (2). Phosphorylation of IkappaB-alpha at
Ser32 and Ser36 has been shown to stimulate conjugation
with ubiquitin and subsequent degradation of
IkappaB-alpha (3). Activation of NF-kappaB can also
be achieved after tyrosine phosphorylation of
IkappaBalpha at tyrosine 42, an event that also
ultimately leads to the dissociation of NF-kappaB
and IkappaBalpha (4). Phosphorylation of IkappaB-alpha
at Ser32 and Tyr42 is critical for activation of
NF-kappaB, which then translocates to the nucleus
and induces transcription of genes that protect
organism (1-5).

Recommended Applications
WB, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:50 - 100
IP: 1:10 - 100
Species Reactivity
Human
Products Data

Western blot analysis on Hela cell lysates
using anti-Phospho-IkappaB-alpha (pS32) RabMAb
(cat. #2798-1). Cells were either (A) untreated (B)
treated with Calyculin A and TNF-a

Specificity
A phospho specific peptide corresponding to
residues surrounding Serine 32 of human IkappaB-alpha
was used as an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR3148
【用途】WB , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】40kDa
贮存 Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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