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Recombinant Human Bone Morphogenetic Protein-3B
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| 性状 | Recombinant Human Bone Morphogenetic Protein-3B 属于转化生长因子 β 超家族，与骨形态发生蛋白-3 (BMP3) 密切相关。Recombinant Human Bone Morphogenetic Protein-3B 在头部形成中起作用，且在骨骼形态发生中具有多种作用。
Synonyms rHuBMP-3B; BIP; BMP-3B; GDF-10 Species Human Source E. coli Accession P55107 Gene ID 2662 Molecular Weight Approximately 25.1 kDa AA Sequence MQWDEPRVCS RRYLKVDFAD IGWNEWIISP KSFDAYYCAG ACEFPMPKIV RPSNHATIQS IVRAVGIIPG IPEPCCVPDK MNSLGVLFLD ENRNVVLKVY PNMSVDTCAC R Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 4 mM HCl. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Bone Morphogenetic Protein-3B (rHuBMP-3B) to 100 µg/mL using 4 mM HCl. Storage & Stability Lyophilized recombinant Human Bone Morphogenetic Protein-3B (rHuBMP-3B) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classified into two subclasses, i.e. those activated by activin and TGF-beta signaling pathways (AR-Smads), and those activated by bone morphogenetic protein (BMP) pathways (BR-Smads). The numbers of type II and type I receptors and Smad proteins are limited. Thus, signaling of the TGF-beta superfamily converges at the receptor and Smad levels. In the intracellular signaling pathways, Smads interact with various partner proteins and thereby exhibit a wide variety of biological activities. Moreover, signaling by Smads is modulated by various other signaling pathways allowing TGF-beta superfamily ligands to elicit diverse effects on target cells. Perturbations of the TGF-beta/BMP signaling pathways result in various clinical disorders including cancers, vascular diseases, and bone disorders[1]. |
| 贮存 |
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