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Recombinant Mouse Betacellulin

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132842-10 μg 0 ￥3800 请登录
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1308132842-50 μg 0 ￥9800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Betacellulin 是 E. coli 产生的表皮生长因子家族的一员，可诱导胰腺 β 细胞的分化，促进 β 细胞的再生。
Synonyms
rMuBetacellulin; BTC
Species
Mouse

Source
E. coli

Accession
Q05928

Gene ID
12223

Molecular Weight
Approximately 9.2 kDa

AA Sequence
MDGNTTRTPE TNGSLCGAPG ENCTGTTPRQ KVKTHFSRCP KQYKHYCIHG RCRFVVDEQT PSCICEKGYF GARCERVDLF Y

Biological Activity
The ED50 is <0.5 ng/mL as measured by 3T3 cells, corresponding to a specific activity of >2 × 106 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 50 mM Tris, 300 mM NaCl, pH 9.0.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Mouse Betacellulin (rMuBetacellulin) to 100 µg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Mouse Betacellulin (rMuBetacellulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, induces differentiation of pancreatic β-cells and promotes regeneration of β-cells in experimental diabetes. BTC stimulates DNA synthesis in fibroblasts and vascular smooth muscle cells. BTC plays a role in regulating growth and/or differentiation of endocrine precursor cells of the fetal pancreas. BTC is found to convert amylase-secreting pancreatic AR42J cells into insulin-producing cells and to have a mitogenic effect in human undifferentiated pancreatic epithelial cells[1].
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