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LAT Phospho (pY191)
英文名：LAT Phospho (pY191)
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114486-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | 36 kDa phospho-tyrosine adapter protein, pp36, p36-38 |
| Cas号 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 产品参数 | 【产品介绍】LAT (linker f o r activation of T-cells)
is involved in the T-cell antigen recept o r (TCR) signal transduction pathway, a n d may play an imp o r tant role downstream in activating protein tyrosine kinases (1). LAT is phosph o r ylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 a n d Tyr171 are required f o r T-cell activation a n d Tyr132 is required f o r the activation of PLCgamma1 a n d Ras signaling pathways, respectively. Tyr226 a n d Tyr191 are required f o r Vav binding, whereas Tyr171 a n d Tyr132 are necessary f o r association a n d activation of phosphoinositide 3-kinase activity a n d PLCgamma1 (3). WB: 1:2,000 IHC: 1:50 ICC: 1:50 IP: 1:10 A. Western blot analysis on Jurkat cell lysate using anti-Phospho-LAT (pY191) RabMAb (cat. #1225-1); dilution 1:2,000. (1) Jurkat plus anti-CDC a n d (2) Jurkat negative control. B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Phospho-LAT (pY191) RabMAb (cat. #1225-1). |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat 【克隆 ID】E225 【用途】WB , IHC , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】36/38 kDa |
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