IFN alpha R1

英文名:IFNAR1
Cas号:
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别 名 IFNAR1 antibody, AVP antibody, IFN-alpha-REC antibody, IFNAR antibody, IFNBR antibody, IFRC antibody, Interferon alpha/beta receptor 1 antibody, Type I interferon receptor 1 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Interferon alpha receptor 1 (IFN alpha R1) is
a class II cytokine receptor that belongs to the type
I human interferons (IFNs) family. IFNs plays a role
in antiviral, antiproliferative,
immunomodulatory, antitumor, and antiparasitic activities
by inducing transcription of IFN-stimuated genes
(ISGs) through activation of the Jak-STAT
pathway. Specifically, IFN alpha R1 is a 135-kDa
signal transducing subunit of the IFN alpha/beta
receptor complex (IFN-α R) (1). IFN alpha R1
is phosphorylated through PTK- and PKC-
mediated phosphorylation, which initiates docking of
STAT proteins to IFNs. This leads to activation of
STAT proteins by PTK-mediated phosphorylation. The
mechanism behind the amplification of IFN alpha R
complex mediated transmembrane signaling has been linked
to tyrosine phosphorylation on IFN alpha R1 (2).

Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
Species Reactivity *
Human, Mouse, Rat
*Species cross-reactivity is based on WB analysis.
Products Data

Western blot analysis on (A) HeLa, (B) HeLa treated
with IFN-alpha, (C) K562, and (D) U937 cell lysates
using anti-IFN alpha R1 RabMAb (cat. #5330-1).

Specificity
A synthetic peptide corresponding to residues in human
IFN alpha R1 was used as an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6244
【用途】WB
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】90-130kDa
贮存 Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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