Alpha-Actinin 1

英文名:Alpha-Actinin 1
Cas号:
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别 名 ACTN1, Alpha-actinin-1, Alpha-actinin cytoskeletal isoform;Non-muscle alpha-actinin-1;F-actin cross-linking protein
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Alpha-actinin is a ubiquitously
expressed protein found in numerous actin structures.
It consists of an N-terminal actin binding domain, a
central rod domain, a n d a C-terminal domain
a n d functions as a homodimer to cross-link
actin filaments. The rod domain determines the
distance between cross-linked actin filaments a n d
also serves as an interaction site f o r
several cytoskeletal a n d signaling proteins (1).
Alpha-actinins are a multigene family of four
actin-binding proteins related to dystrophin.
Alpha-actinin-1 a n d -4 (ACTN1, ACTN4) are non-muscle
isof o r ms version of ACTN. These isof o r m are
commonly expressed in filopodia, lamellipodia,
stress fibers, sites of adhesion a n d
intercellular contacts (2).

Recommended Applications
WB, FC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000-10,000
FC: 1:10-100
IP: 1:10-100
Species Reactivity *
Human, Mouse, Rat
* *Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on (A) NIH 3T3 (B) HeLa (C)
C6 lysates using anti-alpha-actinin 1 RabMAb
(cat. # 2279-1), dilution 1:10,000.

Specificity
A synthetic peptide corresponding to residues on
the N-terminus of human Alpha-Actinin 1 was used
as an immunogen.
性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat 【克隆 ID】EP2527Y
【用途】WB , IHC , FC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】100 kDa
贮存 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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