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FGF Receptor 1 (C-term) (FGFR1)
英文名：Rabbit Monoclonal Antibody
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113584-100ul | 现货 | 0 | ￥0 |
| 别 名 | FGFR1 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR-1 antibody, FLG antibody, FLJ99988 antibody, FLT-2 antibody, FLT2 antibody, HBGFR antibody, KAL2 antibody, N-SAM antibody, OGD antibody, bFGF-R-1 antibody, Basic fibroblast |
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| 产品参数 | 【产品介绍】Fibroblast growth factors (FGFs) are
polypeptide mitogens that induce the proliferation of a wide variety of cell types (1). Fibroblast growth factor (FGF)/FGF receptor (FGFR1) signaling plays a crucial role in mesoderm formation and patterning. Studies suggest that FGFR1, among the different FGFRs, may play a role in cardiogenesis. Data point to a nonredundant role for FGFR1-mediated signaling in cardiomyocyte development (2). It has also been shown that during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium (3). Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing (4). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:500 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on SH-SY-5Y cell lysate using anti-FGFR1 RabMAb (cat. # 2144-1), dilution 1:500. Specificity A synthetic peptide corresponding to residues near the C-terminus of human FGFR1 was used as an immunogen. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR806Y 【用途】WB 【抗原分子量】130kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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