DNA-PK / PRKDC

英文名:Rabbit Monoclonal Antibody
Cas号:
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货号 规格 货期 库存 价格 会员价 订购
1308113516-100ul 现货 0 ¥0 请登录
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别 名 PRKDC antibody, DNA-PKcs antibody, DNAPK antibody, DNPK1 antibody, HYRC antibody, HYRC1 antibody, XRCC7 antibody, p350 antibody, DNA-dependent protein kinase catalytic subunit antibody, DNPK1 antibody, p460 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】DNA-activated serine/threonine protein
kinase (DNA-PK) is a nuclear protein kinase that is
involved in DNA nonhomologous end joining (NHEJ)
required for double- strand brake repair and
V(D)J recombination. DNA-PK is composed of a
large catalytic subunit of ~470 kDa (DNA-PKcs) and a
DNA binding heterodimer of approximately 70- and
80-kDa subunits called Ku. (1-2). Autophosphorylation
of DNA-PK correlates with loss of protein kinase
activity and dissociation of the DNA-PKcs-Ku complex.
DNA-PK phosphorylates Hsp90, p53 and c-Jun (3-4).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:500 - 1000
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis

Products Data

Western blot analysis on (A) K562, (B) Molt-4,
(C) MCF-7, (D) SH-SY5Y, (E) 293T, and (F) PC-3 cell
lysates using anti-DNA-PK / PRKDC RabMAb (cat. #3922-1).

Specificity

A synthetic peptide corresponding to residues in
human DNA-PK / PRKDC was used as an immunogen.
性状 【反应特异性】Human
【克隆 ID】EPR392
【用途】WB , ICC
【抗原分子量】460kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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