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Cytokeratin 5 (KRT5)

英文名：Rabbit Monoclonal Antibody
Cas号：
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别 名 KRT5 antibody, CK5 antibody, DDD antibody, EBS2 antibody, K5 antibody, KRT5A antibody, Keratin, type II cytoskeletal 5 antibody, Type-II keratin Kb5 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Keratins are cytoplasmic intermediate
filament proteins expressed by epithelial cells.
The mitotically active basal layers of most
stratified squamous epithelia express 10 to 30% of
their total protein as keratin. The two
keratins specifically expressed in these cells are the
type II keratin CK-5 and its corresponding partner, type
I keratin CK-14, both of which are essential for
the formation of 8-nm filaments (1). CK-5 and
calretinin have been useful in different studies
as immunohistochemical markers suggestive of
mesothelioma, and their expression is analyzed for
the histological differential diagnosis
with adenocarcinomas, especially when confronting
with metastatic tumors of unknown origin (2).
Loss-of-function mutations in the keratin 5 gene
(KRT5) affected family members and in six unrelated
patients with Dowling-Degos disease (DDD), an
autosomal dominant genodermatosis. This suggests a
crucial role for keratins in the organization of
cell adhesion, melanosome uptake, organelle transport,
and nuclear anchorage (3).


Recommended Applications

WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:10,000
IHC: 1:100
ICC: 1:250
IP: 1:60
Species Reactivity *

Human

*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on A431 cell lysate using
anti-CK-5 RabMAb (cat. # 2290-1), dilution 1:10,000.

B. Immunohistochemical analysis of paraffin-embedded
human squamous cervical carcinoma using anti-CK-5
RabMAb (cat.#2290-1).

Specificity

A synthetic peptide corresponding to residues in the
head region of human cytokeratin 5 was used as an immunogen.
性状 【反应特异性】Human
【克隆 ID】EPR1600Y
【用途】WB , IHC , ICC , IP
【抗原分子量】59kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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