Caveolin 2 Phospho (pY19) (CAV2)

英文名:Rabbit Monoclonal Antibody
Cas号:
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308113403-100ul 现货 0 ¥0 请登录
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体,下单前请联系客服。
别 名 CAV2 antibody, CAV antibody, MGC12294 antibody, Caveolin-2 antibody, antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Caveolins (Caveolin 1, 2, and 3) are a family
of caveolae-associated integral membrane proteins.
Caveolae are cholesterol/sphingolipid-rich microdomains
of the plasma membrane that have been implicated in
signal transduction and vesicular trafficking (1).
Caveolin 2 is a principal component of caveolae
membranes. It interacts directly with heterotrimeric
guanine nucleotide binding proteins (G proteins) and
can functionally regulate their activity. Caveolins 1
and 2 are similar in most respects; however, they differ
in their functional interactions with heterotrimeric
G proteins, possibly explaining why Caveolin-1 and
-2 are coexpressed within a single cell (2).
Caveolin-2 is up-regulated in response to the
mechanical injury of differentiated PC12 cells, which
is strictly dependent on continued treatment with NGF.
Both Caveolin-1 and -2 are more abundantly expressed
in white adipose tissue and are induced during
adipocyte differentiation. Robust expression of
Caveolin-1 and -2 is also observed along the entire
cell surface of DRG neurons, including high levels on
growth cones (1). Phosphorylation on Tyr-19 is required
for insulin-induced phosphorylation of MAPK1 and DNA
binding of STAT3 (2).


Recommended Applications

WB, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
FC: 1:10 - 100
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis.


Products Data

Western blot analysis on HUVEC cell lysates
using anti-Phospho-Caveolin 2 (pY19) RabMAb
(cat. #3873-1). Cells were either (A) untreated (B)
treated with pervanadate.


Flow cytometric analysis of permeabilized HUVEC
cells, untreated (green) or pervanadate-treated (red)
using anti-Caveolin 2 Phospho (pY19) RabMAb
(catalog # 3873-1), and pervanadate-treated HUVEC
cells using the same antibody preincubated with
phospho-Caveolin 2 Phospho (pY19) peptide (blue)
or non-phospho-Caveolin 2 Phospho (pY19) peptide
(orange).


Specificity

A phospho specific peptide corresponding to
residues surrounding tyrosine 19 of human Caveolin 2.
This antibody detects Caveloin 2 phosphorylated at
tyrosine 19.


性状 【反应特异性】Human
【克隆 ID】EPR2220(3)
【用途】WB , FC
【抗原分子量】20kDa
贮存 Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。
X
QQ