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Recombinant Human Desert Hedgehog

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132851-10 μg 0 ￥3200 请登录
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1308132851-50 μg 0 ￥7800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Desert Hedgehog 是在 E. coli 中产生的一种非糖基化肽链。Desert hedgehog protein (DHH) 是 Hedgehog 家族成员，可编码信号分子，在调节形态发生中起重要作用。

Synonyms
rHuDHH; DHH; HHG-3
Species
Human

Source
E. coli

Accession
O43323

Gene ID
50846

Molecular Weight
Approximately 20 kDa

AA Sequence
IIGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG

Biological Activity
The ED50 is <10 µg/mL as measured by CCL-226 cells, corresponding to a specific activity of >100 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Desert Hedgehog (rHuDHH) to 100 µg/mL using ddH2O.

Storage & Stability
Lyophilized Recombinant Human Desert Hedgehog (rHuDHH) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH signals through the patched (PTCH) receptors 1 and 2. The receptors PTCH1 and PTCH2 are highly conserved mediators of hedgehog signalling in both the developing and adult marsupial gonads. Together these findings indicate DHH is an essential therian mammal-specific morphogen in gonadal development and gametogenesis[1].
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