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Recombinant Human Interleukin-4 Receptor (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132733-10 μg 0 ￥3600 请登录
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1308132733-50 μg 0 ￥12800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Interleukin-4 Receptor (HEK293-expressed) 是I型跨膜蛋白，可以结合白细胞介素-4和白细胞介素-13。
Synonyms
rHuIL-4R; IL4R; IL-4RA; CD124 ; 重组人白细胞介素-4受体 (HEK293表达)
Species
Human

Source
HEK 293

Accession
P24394

Gene ID
3566

Molecular Weight
40-45 kDa

AA Sequence
GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH

Biological Activity
The ED50 is <70 ng/mL as measured by TF-1 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-4 Receptor (HEK293-expressed) (rHuIL-4R) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human Interleukin-4 Receptor (HEK293-expressed) (rHuIL-4R) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells[1].
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