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Recombinant Human Granulocyte Chemotactic Protein-2/CXCL6 (CHO-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132699-10 μg 0 ￥3200
- +
1308132699-50 μg 0 ￥7800
- +
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Granulocyte Chemotactic Protein-2/CXCL6 (CHO-expressed) 是具有抗菌活性的细胞因子，与黏膜感染有关。
Synonyms
rHuGCP-2/CXCL6; CKA-3; SCYB6 ; 重组人粒细胞趋化蛋白2 (CHO细胞表达)
Species
Human

Source
CHO

Accession
P80162

Gene ID
6372

Molecular Weight
Approximately 9 kDa

AA Sequence
VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN

Biological Activity
The ED50 is <0.8 μg/mL as measured by CHO-K1/Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells).

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Granulocyte Chemotactic Protein-2/CXCL6 (CHO-expressed) (rHuGCP-2/CXCL6) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human Granulocyte Chemotactic Protein-2/CXCL6 (CHO-expressed) (rHuGCP-2/CXCL6) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is an ELR-positive CXC chemokine with a length of 77 amino acids. CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. In killed bacteria, GCP-2/CXCL6 associates with bacterial surfaces, which showed membrane disruption and leakage. In the case of leukocytes, GCP-2/CXCL6 binding to the receptors causes cellular activation, chemotaxis, and sometimes, depending on the context, execution of cytotoxic effector functions. Activation of endothelial cells by GCP-2/CXCL6 causes a mitogenic response, resulting in angiogenesis[1].
贮存
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