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Recombinant Human Exodus-2/CCL21

英文名：
Cas号：
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别 名
Cas号
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分子式
分子量
产品参数
性状 Recombinant Human Exodus-2/CCL21 是一种稳态淋巴样趋化因子，有助于T细胞和树突状细胞进入淋巴样T区。
Synonyms
rHuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21 ; 重组人嗜酸性细胞趋化因子 (CCL21)
Species
Human

Source
E. coli

Accession
O00585

Gene ID
6366

Molecular Weight
Approximately 12.2 kDa

AA Sequence
SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P

Biological Activity
Full biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 10-100 ng/ml.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Exodus-2/CCL21 (rHuExodus-2/CCL21) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA.

Storage & Stability
Lyophilized recombinant Human Exodus-2/CCL21 (rHuExodus-2/CCL21) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
CCL21 is a homeostatic chemokine constitutively produced in secondary lymphoid organs (SLOs) where it is involved in CCR7 naı¨ve and central memory T-cell homing via high endothelial venules (HEVs). CCL21CCL21 is also a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cell and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is produced by cells distributed throughout the T zone, whereas high endothelial venules (HEVs) lack CCL21 mRNA[1].
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