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Recombinant Human beta Defensin-2
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| 性状 | Recombinant Human beta Defensin-2 是一种参与对抗微生物入侵反应的抗微生物肽。
Synonyms rHuBD-2; DEFB2 ; 重组人 β-防御素-2 Species Human Source E. coli Accession O15263 Gene ID 1673 Molecular Weight Approximately 4.3 kDa AA Sequence GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P Biological Activity Full biological activity determined by a chemotaxis bioassay using immature human dendritic cells is in a concentration range of 10-100 ng/mL. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human beta Defensin-2 (rHuBD-2) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Human beta Defensin-2 (rHuBD-2) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human β-defensin-2 (HBD-2) is a potent anti-microbial peptide that is part of the innate immune response. HBD-2 is a natural anti-microbial peptide present in amniotic fluid participates in the host response to microbial invasion of the amniotic cavity[1]. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing Gram negative bacteria. Its expression is also up-regulated by the cytokine tumor necrosis factor-alpha[2]. |
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