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Recombinant Human Transforming Growth Factor β1

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132638-10 μg 0 ￥4600
- +
1308132638-50 μg 0 ￥14800
- +
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 TGFβ1是一种多功能细胞因子，参与胎儿发育，控制细胞生长和分化，诱导纤维化，引起免疫应答的抑制，参与血管生成，肿瘤的发展和炎症过程。
Synonyms
TGF-beta-1; TGFB1; TGFB; rHuTGF-β1
Species
Human

Source
CHO

Accession
P01137

Gene ID
7040

Molecular Weight
Approximately 12 kDa

AA Sequence
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

Biological Activity
The ED50 is <0.2 ng/mL as measured by HT-2 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 50 mM NaAc, 50 mM NaCl, pH 5.0.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Transforming Growth Factor β1 (rHuTGF-β1) to 100 µg/mL using ddH2O or diluted with 50 mM Citrate.

Storage & Stability
Lyophilized recombinant Human Transforming Growth Factor β1 (rHuTGF-β1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
TGFβ is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts. Mammals express three isoforms of TGFβdesignated TGFβI, TGFβ2, and TGFβ3; TGFβ1 is the most abundant isoform in all tissues, and in human platelets it is the only isoform of the peptide. Certain cells such as retinal pigment epithelial cells secrete predominantly TGFβ2, and certain body fluids such as the aqueous and vitreous of the eye, amniotic fluid, saliva, and breast milk contain principally TGFβ2. TGFβ3 is the least studied of the TGFβ isoforms. It has been isolated from human umbilical cord and is secreted from certain cells, including myoblast celllines; however, it is usually less abundant than either TGFβ1 or TGFβ2 in both tissue and cell extracts[1]. There are three fundamental directions of its activities: I. TGFβ1 regulates cell proliferation, growth, differentiation and cells movement. II. TGFβ1 has immunomodulatory effects. III. TGFβ1 has profibrogenic effects. TGFβ1 action can be local and systemic[2].
贮存
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
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