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Recombinant Rat Interleukin-6 (HEK293-expressed)

英文名：
Cas号：
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别 名
Cas号
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分子式
分子量
产品参数
性状 Recombinant Rat Interleukin-6 (HEK293-expressed) 是一种 HEK293 细胞来源的多功能细胞因子，可调节各种免疫和炎症反应
Synonyms
rRtIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2
Species
Rat

Source
HEK 293

Accession
P20607

Gene ID
24498

Molecular Weight
21-26 kDa

AA Sequence
FPTSQVRRGD FTEDTTHNRP VYTTSQVGGL ITYVLREILE MRKELCNGNS DCMNSDDALS ENNLKLPEIQ RNDGCFQTGY NQEICLLKIC SGLLEFRFYL EFVKNNLQDN KKDKARVIQS NTETLVHIFK QEIKDSYKIV LPTPTSNALL MEKLESQKEW LRTKTIQLIL KALEEFLKVT MRSTRQT

Biological Activity
The ED50 is <3 pg/mL as measured by 7TD1 Cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Rat Interleukin-6 (HEK293-expressed) (rRtIL-6) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Rat Interleukin-6 (HEK293-expressed) (rRtIL-6) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-6 (IL-6) is one of the most important mediators of the acute phase reaction in liver[1]. Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. IL-6 promotes specific differentiation of naïve CD4+ T cells, thus performing an important function in the linking of innate to acquired immune response. IL-6, in combination with transforming growth factor (TGF)-β, is indispensable for Th17 differentiation from naïve CD4+ T cells, but that IL-6 also inhibits TGF-β-induced Treg differentiation[2].
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