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Recombinant Mouse Granulocyte Colony-stimulating Factor
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| 性状 | Recombinant Mouse Granulocyte Colony-stimulating Factor (CHO-expressed) 是调节嗜中性粒细胞生成的多肽生长因子。
Synonyms rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim Species Mouse Source CHO Accession P09920 Gene ID 12985 Molecular Weight 22-24 kDa AA Sequence VPLVTVSALP PSLPLPRSFL LKSLEQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA RLALHHLA Biological Activity The ED50 is <0.02 ng/mL as measured by NFS-60 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Murine Granulocyte Colony-stimulating Factor (CHO-expressed) (rMuG-CSF) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Murine Granulocyte Colony-stimulating Factor (CHO-expressed) (rMuG-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Granulocyte Colony Stimulating Factor (G-CSF) is a cytokine that normally acts in the bone marrow microenvironment to stimulate blood cell formation. It selectively promotes growth and maturation of neutrophil progenitor cells. Granulocyte Colony Stimulating Factor receptors are present on precursor cells in the bone marrow. By binding to these receptors, Granulocyte Colony Stimulating Factor initiates proliferation and differentiation into mature granulocytes, and also stimulates bone marrow cell release into the circulation. In addition to growth promotion, Granulocyte Colony Stimulating Factor also effects phagocytosis, motility, bactericidal activity and surface molecule expression of neutrophils and monocytes[1][2]. G-CSF production is induced by several inflammatory stimuli that become rapidly elevated during infection such as interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNFα) and lipopolysaccaride (LPS). Therefore, pathogen-mediated activation of host pattern recognition receptors via LPS, and the host cytokine response to infection, serve to induce circulating levels of G-CSF[3]. |
| 贮存 |
- 十五烷基苯 2131-18-2
- 十三烷基苯 123-02-4
- 顺-2-已烯 7688-21-3
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- Recombinant Mouse Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed)
- Recombinant Mouse Insulin-like Growth factor-1
- Recombinant Mouse Interferon-gamma
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