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Recombinant Human Macrophage Colony-stimulating Factor
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| 性状 | Recombinant Human Macrophage Colony-stimulating Factor 是一种造血生长因子，具有多个糖基化位点，能够影响巨噬细胞的生存和功能，同时具有抗肿瘤活性。
Synonyms rHuM-CSF; CSF-1; MGI-IM ; 重组人巨噬细胞群刺激因子 Species Human Source E. coli Accession P09603 Gene ID 1435 Molecular Weight Approximately 28 kDa AA Sequence MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS Biological Activity The ED50 is 1 - 3 ng/mL as measured by M-NFS-60 cells, corresponding to a specific activity of 3.3 × 105 - 1 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Macrophage Colony-stimulating Factor (rHuM-CSF) to 100 µg/mL using ddH2O or PBS or Tris-HCl, pH 8.0. Storage & Stability Lyophilized recombinant Human Macrophage Colony-stimulating Factor (rHuM-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Human Macrophage Colony-stimulating Factor is a hematopoietic growth factor with various glycosylation sites, affects survival and function of the tissue macrophages, and possesses antitumor activity[1]. Macrophage Colony Stimulating Factor (M-CSF) is a pro-inflammatory cytokine, constitutively produced by several cell types, such as fibroblasts, endothelial cells, stromal cells, macrophages, smooth muscle cells and osteoblasts, binds to its receptor CSF1R, and exists in several isoforms- as a secreted glycoprotein, a cell-surface protein and a proteoglycan[2]. M-CSF is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts, which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes seen in patients with rheumatoid arthritis[3] |
| 贮存 |
- Recombinant Human Interleukin-9 (CHO-expressed)
- Recombinant Human Keratinocyte Growth Factor 1/FGF-7
- Recombinant Human Keratinocyte Growth Factor-2/FGF-10
- Recombinant Human Leukemia Inhibitory Factor
- Recombinant Human Macrophage Colony-stimulating Factor
- Recombinant Human Noggin (CHO-expressed)
- Recombinant Human Oncostatin-M, 227a.a.
- Recombinant Human Oncostatin-M, 209a.a.
- Recombinant Human Osteoprotegerin
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