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Recombinant Human Interleukin-1 Receptor Antagonist Protein
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| 性状 | Recombinant Human Interleukin-1 Receptor Antagonist Protein是IL-1家族的成员，可与IL-1受体结合。
Synonyms rHuIL-1RA; IL-1RN; IRAP Species Human Source E. coli Accession P18510 Gene ID 3557 Molecular Weight Approximately 17,258 Da AA Sequence MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE Biological Activity The ED50 is <0.5 ng/mL as measured by D10S cells, corresponding to a specific activity of 2.0 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 7.5, 200 mM NaCl buffer. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-1 Receptor Antagonist Protein (rHuIL-1RA) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Interleukin-1 Receptor Antagonist Protein (rHuIL-1RA) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background The production of Human Interleukin-1 Receptor Antagonist Protein (IL-1ra) is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. Endogenous IL-1Ra is produced in numerous experimental animal models of disease as well as in human autoimmune and chronic inflammatory diseases. Treatment of human diseases with recombinant human IL-1Ra shows an absence of benefit in sepsis syndrome[1]. IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response[2]. |
| 贮存 |
- Recombinant Human Interferon-gamma
- Recombinant Human Interferon-lambda1/Interleukin-29
- Recombinant Human Interleukin-1 alpha
- Recombinant Human Interleukin-1 beta
- Recombinant Human Interleukin-1 Receptor Antagonist Protein
- Recombinant Human Interleukin-10
- Recombinant Human Interleukin-11
- Recombinant Human Interleukin-12
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