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Recombinant Human Insulin-like Growth Factor-Binding Protein 5
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| 性状 | Recombinant Human Insulin-like Growth Factor-Binding Protein 5 是一种独特的胰岛素样生长因子结合蛋白，能够调节胰岛素样生长因子的活动，刺激成骨细胞增殖。
Synonyms rHuIGF-BP5; IBP-5 ; 重组人胰岛素样生长因子结合蛋白 5 Species Human Source CHO Accession P24593 Gene ID 3488 Molecular Weight Approximately 28.3 kDa AA Sequence LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LP Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 20 mM PB, 150mM NaCl, pH 6.2. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstituted the lyophilized Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) in ddH2O at 100 μg/mL. Storage & Stability Lyophilized recombinant Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts[1]. |
| 贮存 |
- Recombinant Human Heparin-binding EGF-like Growth Factor
- Recombinant Human Insulin-like Growth Factor-1
- Recombinant Human Insulin-like Growth factor-2
- Recombinant Human Insulin-like Growth Factor-Binding Protein 3
- Recombinant Human Insulin-like Growth Factor-Binding Protein 5
- Recombinant Human Interferon-alpha2a
- Recombinant Human Interferon-alpha2b
- Recombinant Human Interferon-beta
- Recombinant Human Interferon-gamma
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