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KDR / VEGFR-2
英文名：KDR / VEGFR-2
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114475-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | KDR antibody, CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, Vascular endothelial growth factor receptor 2 antibody, Kinase insert domain receptor antibody, Protein-tyrosine kinase receptor flk-1 antibody |
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| 产品参数 | 【产品介绍】The expression of VEGF and KDR correlates
highly with the normal ocular vascularization in humans, but VEGF may also be necessary for nonvascular retinal developmental functions, especially for the coordination of neural retinal development and the preliminary steps of the establishment of the definitive stable retinal vasculature (1). KDR/flk-1 is one of two receptors for vascular endothelial growth factor, a potent angiogenic peptide. KDR/flk-1 is an early marker for endothelial cell progenitors, and its expression is restricted to endothelial cells in vivo (2). Therapeutic angiogenesis is likely to require the administration of factors that complement each other. Activation of the receptor tyrosine kinase KDR/Flk1 by vascular endothelial growth factor (VEGF) is crucial, but molecular interactions of other factors with VEGF and Flk1 have been studied to a limited extent. Activation of KDR/Flt1 by PGF resulted in intermolecular transphosphorylation of Flk1, thereby amplifying VEGF-driven angiogenesis through KDR/Flk1. Even though VEGF and PGF both bind KDR/Flt1, PGF uniquely stimulated the phosphorylation of specific KDR/Flt1 tyrosine residues and the expression of distinct downstream target genes (3). Recommended Applications WB, IP Applications and Recommended Dilution Factors WB: 1:500 IP: 1:20 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on human placenta lysate using anti-KDR/VEGFR-2 RabMAb (cat. # 2296-1), dilution 1:500. Specificity A recombinant protein corresponding to residues in the extracellular domain of human KDR/VEGFR2 was used as an immunogen. It is predicted that this antibody does not cross react with other members of the VEGF receptor family. |
| 性状 | 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human 【克隆 ID】EPRER16Y 【用途】WB , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】210/230 KDa |
| 贮存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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