IRS-1 Phospho (pY896)

英文名:IRS-1 Phospho (pY896)
Cas号:
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别 名 IRS-1
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Insulin recept o r substrates (IRS), the
maj o r intracellular substrates of the insulin recept
o r (IR), are adapt o r proteins that transduce
signals from the IR to downstream effect o r s that are
imp o r tant f o r the biological effect of insulin
(1-2). After insulin stimulation, IRS proteins are
rapidly phosph o r ylated on multiple tyrosine
residues. Once phosph o r ylated, IRS proteins bind
a n d activate Grb-2, SHP2 a n d the PI3-K p85
subunit (2-3). IRS-1 functions as one of the key regulat
o r s of IR a n d the insulin-like growth fact o r -1
recept o r . Disruption of IRS-1 causes growth retardation
a n d insulin resistance associated with
hypertension, hypertriglyceridemia, a n d
impaired endothelium-dependent vascular relaxation (4-5)

WB: 1:500,000

A. Western blot analysis on 293 cell lysates
using anti-Phospho-IRS-1 (pY896) RabMAb
(cat. #1813-1), 1:500,000 dilution. Cells were either
(A) untreated (B) treated with insulin
性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat
【克隆 ID】EP260Y
【用途】WB
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】170 kDa
贮存
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