HIAP-1/BIR3

英文名:HIAP-1/BIR3
Cas号:
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别 名 Inhibit o r of apoptosis protein 1, HIAP1, HIAP-1, C-IAP2, TNFR2-TRAF-signaling complex protein 1, IAP homolog C, Apoptosis inhibit o r 2, API2, RING finger protein 49
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】cIAP-2, also known as HIAP-1, is a member of
the inhibit o r of apoptosis (IAP) family of proteins.
These proteins contain a BIR (baculovirus IAP repeat)
domain near the amino-terminus (1). cIAP-2 is localized
to the cytoplasm. The BIR motifs region interacts with
TNF recept o r associated fact o r s 1 a n d 2 (TRAF1
a n d TRAF2) to f o r m a heteromeric complex, which is
then recruited to the tum o r necrosis fact o r recept o r
2 (TNFR2). This complex is thought to play a role
in inhibition of apoptosis (2,3). cIAP-2 inhibits
cytochrome c-induced activation of caspase-9,
thereby preventing initiation of the caspase cascade
a n d apoptosis (4).

WB: 1:500
IHC: 1:50
ICC: 1:100
IP: 1:50

A. Western blot analysis on Daudi cell lysate
using anti-HIAP-1/BIR3 RabMAb (catalog #1040-1),
dilution 1:1,000.

B. Immunohistochemical analysis of human n o r mal
spleen using anti-HIAP-1/BIR3 RabMAb (catalog #1040-1).
性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Rat
【克隆 ID】E40
【用途】WB , IHC , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】72 kDa
贮存
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