|
|
|
| 生化科研试剂 >> 抗体产品 >> 一抗 |
| |
GRP170 / ORP150 (HYOU1)
GRP170 / ORP150 (HYOU1) |
| 别 名： |
HYOU1 antibody, DKFZp686N08236 antibody, FLJ94899 antibody, FLJ97572 antibody, Grp170 antibody, HSP12A antibody, ORP150 antibody, Hypoxia up-regulated protein 1 antibody, 170 kDa glucose-regulated protein antibody |
| 货号 |
品名 |
规格 |
包装 |
单价 |
货期 |
库存 |
| 1227178932 |
GRP170 / ORP150 (HYOU1) |
|
100ul |
询价 |
现货 |
3天 |
| 提示信息：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。 |
| 性 状： |
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5890
【用途】WB , IHC , FC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】150kDa |
| 质量标准： |
【产品介绍】GRP170 / ORP150 belongs to the heat
shock protein 70 family. It uses alternative
transcription start sites. A cis-acting segment found in
the 5' UTR is involved in stress-dependent
induction, resulting in the accumulation of this protein
in the endoplasmic reticulum (ER) under hypoxic
conditions. GRP170 / ORP150 is thought to play an
important role in protein folding and secretion in the
ER. Since suppression of the protein is associated
with accelerated apoptosis, it is also suggested to have
an important cytoprotective role in hypoxia-induced
cellular perturbation. This protein has been shown to
be up-regulated in tumors, especially in breast tumors,
and thus it is associated with tumor invasiveness.
GRP170 / ORP150 also has an alternative
translation initiation site, resulting in a protein
that lacks the N-terminal signal peptide. This
signal peptide-lacking protein, which is only 3 amino
acids shorter than the mature protein in the ER, is
thought to have a housekeeping function in the cytosol.
In rat, this protein localizes to both the ER by a
carboxy-terminal peptide sequence and mitochondria by
an amino-terminal targeting signal (1).Recommended Applications
WB, IHC, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
FC: 1:10 - 100
Species Reactivity *
Human, Mouse, Rat
*Species cross-reactivity is based on WB analysis Products Data Western blot analysis on (A) fetal liver, (B) rat liver,
(C) rat pancreas, (D) 293T, (E) MCF-7, (F) MDA-MB-435S,
(G) SH-SY5Y, and (H) HeLa lysates using anti-GRP170 /
ORP150 RabMAb (cat. #3905-1). Immunohistochemical analysis of paraffin-embedded
human liver tissue using anti-GRP170 / ORP150 RabMAb
(cat. #3905-1). Specificity
A synthetic peptide corresponding to residues in
human GRP170 / ORP150 was used as an immunogen.
|
| 贮 存： |
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt. |
|
沪公网安备 31012002003054号
