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FAK Phospho (pY576)
英文名：Rabbit Monoclonal IgG
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113574-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | FADK 1, pp125FAK, Protein-tyrosine kinase 2 |
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| M D L | |
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| 产品参数 | 【产品介绍】Focal adhesion kinase (FAK) is a non-recept
o r protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation a n d apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- a n d C-terminal regions. FAK is activated by phosph o r ylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion o r antibody cross-linking o r via G-protein-coupled recept o r (GPCR) occupancy by lig a n d s such as bombesin o r lysophosphatidic acid (2-3). Phosph o r ylation of FAK Tyr-397 c r e a t e s a binding site f o r Src-family kinases, a n d phosph o r ylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity (4). Increased FAK expression has been c o r related with the enhanced motility a n d invasiveness of human tum o r cells, as well as with promoting increased cell proliferation (5). WB: 1:50,000 100,000 Flow Cytometry: 1:50 A. Western blot analysis on 3T3 cell lysates using anti-Phospho-FAK (pY576) RabMAb (cat. #2103-1), 1:50,000 dilution. Cells were either (A) untreated (B) treated with pervanadate. |
| 性状 | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP1987Y
【用途】WB , FC 【抗原分子量】125 kDa |
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