E-Cadherin (CDH1)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 CDH1 antibody, Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, E-Cad/CTF3 antibody, Uvomorulin antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】E-Cadherin is a classical cadherin from
the cadherin superfamily. It is a calcium
dependent cell-cell adhesion glycoprotein comprised of
five extracellular cadherin repeats, a transmembrane
region and a highly conserved cytoplasmic tail. Mutations
in E-Cadherin protein are correlated with gastric,
breast, colorectal, thyroid and ovarian cancer. Loss
of function is thought to contribute to progression
in cancer by increasing proliferation, invasion,
and/or metastasis. The ectodomain of this protein
mediates bacterial adhesion to mammalian cells and
the cytoplasmic domain is required for
internalization. Identified transcript variants arise
from mutation at consensus splice sites (1).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:100 - 250
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data
Western blot analysis on (A) A431, (B) MCF-7,
(C) Caco-2, and (D) HeLa cell lysates using
anti-E-Cadherin RabMAb (cat. #5409-1).

Specificity

A synthetic peptide corresponding to residues in
human E-Cadherin was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR699
【用途】WB , ICC
【抗原分子量】135kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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