Cytochrome P450 17A1 (CYP17A1)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 CYP17A1 antibody, CPT7 antibody, CYP17 antibody, P450C17 antibody, S17AH antibody, Steroid 17-alpha-hydroxylase/17,20 lyase antibody, Steroid 17-alpha-monooxygenase antibody
Cas号
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分子式
分子量
产品参数 【产品介绍】Cytochrome P450 17A1 is a member of
the cytochrome P450 superfamily of enzymes. The
cytochrome P450 proteins are monooxygenases that
catalyze many reactions involved in drug metabolism
and synthesis of cholesterol, steroids and other lipids.
It localizes to the endoplasmic reticulum. It has
both 17alpha-hydroxylase and 17,20-lyase activities and is
a key enzyme in the steroidogenic pathway that
produces progestins, mineralocorticoids,
glucocorticoids, androgens, and estrogens. Mutations
in Cytochrome P450 17A1 are associated with
isolated steroid-17 alpha-hydroxylase deficiency,
17-alpha-hydroxylase/17,20-lyase
deficiency, pseudohermaphroditism, and adrenal
hyperplasia (1).


Recommended Applications

WB, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:100 - 250
IP: 1:10 - 100
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) human adrenal gland,
(B) SK-OV-3, (C) HeLa, and (D) Jurkat lysates
using anti-Cytochrome P450 17A1 RabMAb (cat. #5419-1).

Immunofluorescent staining of HeLa cells
using anti-Cytochrome P450 17A1 RabMAb (cat.# 5419-1).

Specificity

A synthetic peptide corresponding to residues in
human Cytochrome P450 17A1 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6293
【用途】WB , ICC , IP
【抗原分子量】55kDa
贮存 Storage Condition and Buffer Store at -20° C. Buffer: PBS (pH 7.2), 50% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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