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CHAF1A

英文名：Rabbit Monoclonal Antibody
Cas号：
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别 名 CHAF1A antibody, CAF-1 antibody, CAF1 antibody, CAF1B antibody, CAF1P150 antibody, MGC71229 antibody, P150 antibody, Chromatin assembly factor 1 subunit A antibody, Chromatin assembly factor I p150 subunit antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Chromatin assembly factor I (CAF1) is a
nuclear complex consisting of p50, p60, and p150
(CHAF1A) subunits (1). CHAF1A regulates the formation
of heterochromatin in mammalian cells during
replication. This subunit exists in a
chromatin-remodeling complex WINAC, which coactivates
ligand-induced transactivation function of the vitamin
D receptor (2). As a histone chaperone, the CAF1
complex deposits histones H3/H4 onto DNA in a
replication-dependent manner. CAF1 is required for
cell proliferation and early development in
animals. Proliferating cell nuclear antigen (PCNA) and
CAF1 association has also been linked to DNA repair,
in particular nucleotide excision repair, and to
major mechanisms of double strand break (DSB) repair,
such as homologous recombination (HR) and nonhomologous
end joining (3). Furthermore, CAF1 is involved in
the regulation of cell differentiation and cell
cycle duration (3).


Recommended Applications

WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis.


Products Data

Western blot analysis on (A) Jurkat, (B) HeLa treated
with Hydroxyurea, (C) HeLa, and (D) K562 cell lysates
using anti-CHAF1A RabMAb (cat. #5464-1).

Immunohistochemical analysis of paraffin-embedded
human colon tissue using anti-CHAF1A RabMAb (cat. #5464-1).

Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-CHAF1A RabMAb (cat. #5464-1).

Specificity

A synthetic peptide corresponding to residues in
human CHAF1A was used as an immunogen.
性状 【反应特异性】Human
【克隆 ID】EPR5576(2)
【用途】WB , IHC , ICC , FC , IP
【抗原分子量】150kDa
贮存 Storage Condition and Buffer Store at -20° C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
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