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CD3 epsilon (CD3E)

英文名：Rabbit Monoclonal Antibody
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308113420-100ul 现货 0 ￥3000 请登录
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偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。
别 名 CD3E antibody, FLJ18683 antibody, T3E antibody, TCRE antibody, T-cell surface glycoprotein CD3 epsilon chain antibody, T-cell surface antigen T3/Leu-4 epsilon chain antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】CD3 (Cluster of Differentiation 3) is a
complex of proteins that associates directly with the T
cell antigen receptor (TCR) (1). Antigen binding to the
TCR leads to IL-2 secretion via activation of a
tyrosine phosphorylation pathway and a phospholipase C
(PLC) pathway, in turn activating protein kinase
C (1,2). CD3 is composed of five invariant
polypeptide chains that associate to form three dimers.
The five invariant chains of CD3 are labeled gamma,
delta, epsilon, zeta, and eta. The gamma, epsilon and
delta chains each contain a single copy of a
conserved immunoreceptor tyrosine-based activation
motif (ITAM). Phosphorylated ITAMs act as docking sites
for protein kinases such as ZAP-70 and Syk (3).


Recommended Applications

WB, IHC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:250 - 500
IP: 1:50
Species Reactivity *

Human

*Cross reactivity determined by western blot only.


Products Data

A. Western blot analysis on Jurkat cell lysate of
using anti-CD3 epsilon Rabbit Monoclonal (cat. # 1774-1).

B. Immunohistochemical analysis of paraffin-embedded
human spleen using anti-CD3 epsilon Rabbit Monoclonal
(cat. #1774-1).

Specificity

A synthetic peptide corresponding to residues in
cytoplasmic domain of human CD3 epsilon was used
as immunogen. The antibody does not cross-react with
other subunits of CD3.

性状 【反应特异性】Human
【克隆 ID】EP449E
【用途】WB , IHC , IP
【抗原分子量】23kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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