Bim

英文名:Rabbit Monoclonal IgG
Cas号:
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别 名
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Bim, Bcl-2 interacting mediat o r of cell
death, is a pro-apoptotic protein belonging to the
BH3-only group of Bcl-2 family members (1). Bim
promotes apoptosis by binding to a n d inhibiting
the activity of anti-apoptotic Bcl-2 family
members, inducing the release of cytochrome c
from mitochondria (2). Bim is sequestered in an
inactive conf o r mation through binding to the
microtubule-associated dynein mot o r complex.
Certain apoptotic stimuli release Bim from
microtubules, allowing inhibit o r y binding
to anti-apoptotic Bcl-2 family members a n d
subsequent iniation of apoptosis (3,4).


WB: 1:500
IHC: 1:100
ICC: 1:100
IP: 1:40

A. Western blot analysis on A431 cell lysate using
anti-Bim RabMAb (cat. #1036-1), dilution 1:500.

B. Immunohistochemical analysis of paraffin-embedded
breast carcinoma using anti-Bim RabMAb (cat. #1036-1).

性状 【反应特异性】Human
【克隆 ID】Y36
【用途】WB , IHC , ICC , IP
【抗原分子量】22 kDa
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